[2] The property, established in 1839, was bounded by the Moonee Ponds Creek to the west, Gaffney Street to the south, Northumberland Road to the east and Rhodes Parade to the north.

John Pascoe Fawkner built a timber house overlooking the creek, in the Marie Street area of Oak Park.

In 1841, Dr Farquhar McCrae, a wealthy surgeon, bought land in Pascoe Vale South, where he built his house in 1842–1843.

In 2020, VicRoads announced a project to provide safer cycling infrastructure in Pascoe Vale, including upgrades to bicycle lanes and six intersections between Boundary Road and O'Hea Street.

Light rail service is provided by tram route 58, which terminates at Bell Street, Pascoe Vale South.

Pascoe Vale is located in the federal electorate of Wills, and is historically a safe Australian Labor Party seat.

From 2014 to 2022, the seat was held by the ALP's Lizzie Blandthorn, who is the goddaughter of her predecessor and former Community Services minister Christine Campbell.

Managed by the City of Merri-bek, the Pascoe Vale Swimming Pool, on Prospect Street, is a popular venue during summer.