In 1748, Bartholomew Mosse bought land from William Naper on Parnell Street to construct the Rotunda Hospital.

A significant portion of the original Georgian and Victorian architecture was destroyed, with numerous houses demolished and subsequently replaced mostly by apartment buildings of a much larger scale.

A Stringfellow's restaurant and strip club operated on Parnell Street for a number of months before closing because of poor trading performance.

The eastern end of Parnell Street, having remained comparatively undeveloped, is now home to a thriving immigrant community.

One of the first people to open a Chinese restaurant in Dublin, William Wong, stated it was an Irish missionary Dominican nun who encouraged him to emigrate to Ireland with his family.