By 1961, he was a founding member of the União Nacional dos Estudantes Moçambicanos (UNEMO) and, successively, General secretary and Vice-president of this student organisation.
After concluding his studies, he worked in Switzerland, as Assistant Doctor at St. Loup Hospital from 1973 to 1975, having passed his internship (surgery, obstetrics, medicine and paediatrics).
As holder of the diplomacy brief, he contributed enough to the neutralisation of the external factors of the destabilisation and normalisation of the relationships of Mozambique with the West, in the peace process then in course in the country.
He gave a special contribution in the co-ordination of the Government's effort for the reconstruction, control of the inflation and economic growth, between 1994 and 1999.
The initiative emphasises the need for wide-ranging partnerships to launch an attack on poverty and ill-health to stem the spread of disease.
The South African Malaria Initiative was initiated in 2005 by the African Centre for Gene Technologies, a joint venture between the Universities of Pretoria and Witwatersrand, as well as the Council for Scientific and Industrial Research (CSIR), Africa's single biggest research organisation.
Between 2004 and 2013, Mocumbi served as the High Representative of the European and Developing Countries Clinical Trials Partnership (EDCTP).
[4] Mocumbi was awarded, nationally, the medals of "Trabalho Socialista", "20 Anos da FRELIMO", "Veterano da Luta de Libertação Nacional", and abroad, with other honours such as "Ordem Grande Cruzeiro do Sul" from Brazil, in 1992, and "Grau Cruz – Ordem de Bernardo O'Higgins" from Chile, in 1993.