Classes were conducted in the buildings on the permanent site in Lake Avenue in February 1957.

A foundation ceremony was held, at which the Director of Education, Mr. A. McDonell, unveiled a plaque to commemorate the completion of the main building.

In 1968, the E.D Daniel Assembly Hall was officially opened, and enrolments continued to increase, despite the fact that there was no sixth form and the most talented students had to transfer to other schools to continue their final year of education.

1995 heralded a new era when, under the Schools of the Future program, Pascoe Vale Girls Secondary College officially became a self-managing one and in 2002 was renamed Pascoe Vale Girls College.

With a population of over 800 girls, the college attracts students from a wide geographical area and from diverse cultural backgrounds.