Patrica is a hill-top comune (municipality) in the Province of Frosinone in the Italian region Lazio.

It is at 450 m MSL on a hill that rises, close to the Lepini Mountains, in a dominant position and overlooks the Sacco Valley.

The territory of the comune borders Ceccano, Frosinone (the capital of the province), Giuliano di Roma, and Supino.

Shortly before the Roman expansion, the surrounding region was inhabited by Italic peoples speaking Osco-Umbrian languages.

The Italian community there continues to celebrate each August the Feast of San Rocco, patron saint of Patrica.