Patricia Espinosa Cantellano (born October 21, 1958) is a Mexican diplomat who served as the executive secretary of the United Nations Framework Convention on Climate Change from 2016 to 2022.

She was Secretary of Foreign Affairs in the cabinet of President Felipe Calderón; and served as Mexican Ambassador to Austria, Germany, Slovenia and Slovakia.

Ambassador Cantellano has served as responsible for economic affairs, Permanent Mission of Mexico to UN, Geneva (1982-88); Head, Cabinet to Undersecretary of Foreign Affairs (1989-91); Director of International Organizations (1991-93); assigned to Permanent Mission of Mexico to UN, New York (1993-97); President of the Third Committee, UN General Assembly (1996-97); and General Director of Regional Organizations of the Americas, Ministry of Foreign Affairs, Coordinator for Rio Group, Iberoamerican Summit, Summit of Americas and Summit of Latin America and Caribbean with European Union (1997-99).

[1] On November 28, 2006, President-elect Felipe Calderón announced that she would serve as his Secretary of Foreign Affairs starting on December 1, 2006.

Under her leadership, she led the transformation of the organization towards supporting the full implementation of the Paris Agreement globally.