Patrick D'Silva

He is known for his medical discoveries related to neurodegenerative diseases and cancer biology.

[1] Patrick D'Silva serves as an associate professor at the Division of Biological Sciences of the Indian Institute of Science[2] and heads the Molecular Chaperone Lab as its principal investigator.

[5] On further studies, he found out that the chaperone acts as a detoxifier by removing a toxic metabolite named Methylglyoxal (MG) and regulates reactive oxygen species (ROS).

[6] This led to further investigations and DJ-1, a protein similar to Hsp31, helped to enhance natural detoxifiers such as glutathione (GSH) which in turn regulated the reactive oxygen species and this discovery promised to offer new ways in the management of some forms of Parkinson's disease.

[4] Later, D'Silva and his team furthered their research and developed a metal oxide nanomaterial, which when introduced into humans, acted similar to three major cellular antioxidant enzymes which regulated the level of reactive oxygen species inside cells.