After transitioning into his professional career, Preciado and his newfound partner, Alberto Perez, began to hold empowerment forums in impoverished communities.

Since January 2013, Preciado has regularly contributed to French newspaper Libération′s website Liberation.fr, in a column having gender, sexuality, love and biopower as recurrent themes.

[9] In 2023, ArtReview named Preciado the 22nd most influential person in the contemporary art world, describing his work as "a mainstay reference for the artworld".

[18] Preciado described the act of taking testosterone as both political and performance, aiming to undo a notion of gender encoded in one's own body by a system of sexuality and contraception.

[19] In the work, Preciado describes and analyses the changes provoked by the testosterone from the point of view of the relationship with Virginie Despentes (referred to as "VD" in the book).

On 17 November 2019, Preciado gave a speech before the École de la Cause Freudienne (School of the Freudian Cause)—a society of Lacanian psychoanalysts—in which he described his life as a trans man and challenged the precepts of psychoanalysis.

Preciado claims that he faced booing and heckling, and was only able to read a quarter of his prepared speech before he was told his time had run out.

Second, Preciado noted that psychology and medicine invented vocabulary throughout the twentieth century (e.g. transexual, intersex) to describe exceptions to the notion of the gender binary, and also to pathologize them while preserving the disciplines' paradigmatic frameworks.