He was named the NBA Most Improved Player in 2013, when he also earned his first All-Star selection and led the team to their first Eastern Conference Finals trip since 2004.

George suffered a broken leg in 2014 while competing for a roster spot on the United States national team for the FIBA Basketball World Cup.

[15] Despite the loss, he made an impression with his one-handed slam dunk over Mickey McConnell that earned him SportsCenter's number 1 "Play of the Day" for November 18, 2008.

[2] He made his return on February 11, scoring a career-high 30 points in a winning effort over eventual WAC tournament champion New Mexico State.

[19] On March 31, 2010, George announced that he would forgo his final two seasons of college eligibility at Fresno State and enter the 2010 NBA draft.

Sports wrote an article about an anonymous Eastern Conference scout stating that "in five years, Paul George will be the best player to come out of this draft".

[24] On July 1, 2010, he signed his rookie contract with the Pacers; a two-year guaranteed deal worth $3.9 million, with team options for a third and fourth year.

[25] On October 27, George made his NBA debut against the San Antonio Spurs, playing 23 minutes and scoring 4 points on 1–5 shooting.

[1][28] On February 3, 2012, George recorded 30 points, 7 three-pointers made, 9 rebounds, 5 assists, 5 steals, and 1 blocked shot in a win against the Dallas Mavericks.

After beating the Orlando Magic, who were without Dwight Howard, in five games in the first round, the Pacers lost to the eventual NBA champions, the Miami Heat, 4–2 in the Eastern Conference Semifinals, with George making just 19 of 52 field goals.

[35] George was named the NBA's Player of the Week for the first time in his career in December, winning three straight games against Cleveland, Philadelphia, and Detroit.

Despite George making all 3 free-throws and putting his team up 102–101, the Pacers ultimately lost as LeBron James drove in for a buzzer beater lay-up.

[59][60] During the 2014 off-season, George was named to the training camp roster for the US national team that would represent the country at the 2014 FIBA Basketball World Cup in Spain.

[61] George had been considered a virtual lock to make the roster, but he landed awkwardly at the base of a basket stanchion after fouling James Harden during a Las Vegas scrimmage on August 1, and suffered a compound fracture of both bones in his lower right leg.

[64] He participated in his first full practice of the season on February 26, three days earlier than expected,[65] and was ruled a possibility to play within a week on March 20.

He scored 13 points in 15 minutes and made two key three-pointers early in the fourth quarter, helping the Pacers defeat the Miami Heat 112–89.

George led the Eastern Conference and ranked fourth in the NBA in scoring (27.2 ppg), helping the Pacers win 11 of 13 games after an 0–3 start.

[78] On November 1, he scored 30 points, including Indiana's final 12 of the game, to rally the Pacers to a 115–108 win over the Los Angeles Lakers.

[79] On December 10, he scored a then season-high 37 points, including 13 straight in the fourth quarter, to lead the Pacers to a 118–111 win over the Portland Trail Blazers.

[80] On January 29, 2017, he scored 33 points in a 120–101 win over the Houston Rockets, matching a career high by topping the 30-point mark for the fourth straight game.

[86][87] The Thunder acquired him in spite of his pending free agent status the following year and George's stated preference to join the Los Angeles Lakers in his native Southern California.

[104] On December 5, he scored 25 of his 47 points in the fourth quarter, including a go-ahead 3-pointer with 3.1 seconds left that gave the Thunder a 114–112 victory over the Brooklyn Nets.

[128] George's dismal performance in Game 7 included one memorable miss on a three-point shot attempt in which the ball hit the side of the backboard.

[131] On December 22, George scored 33 points, 26 of which being in the second half, to lead the Clippers to a 116–109 season-opening victory over the defending champion Los Angeles Lakers.

[133] Playing against the Phoenix Suns in his third career Conference Finals, George dropped a playoff career-high 41 points, alongside 13 rebounds and six assists in a crucial 116–102 Game 5 victory.

[138] On March 29, 2022, his first game back from injury, George scored 34 points, delivered six assists along with four steals in a 121–115 comeback victory over the Utah Jazz.

[146] The next day, the Clippers announced that George was diagnosed with a right knee sprain and would be re-evaluated in two-to-three weeks, ending his regular season run.

[150] On January 16, George scored a then season-high 38 points on 15-of-24 shooting and 6-of-12 from three with seven rebounds, five assists, three steals and zero turnovers in a 128–117 win over the Oklahoma City Thunder.

[168] Early in his career, he was unable to create shots for himself and lacked a great deal of ball handle, something he worked on with trainer Jerry Powell during the 2012 off-season.

[169] With All-Star swingman Danny Granger injured during the 2012–13 season, George took on a larger offensive responsibility, which resulted in the NBA Most Improved Player Award.