[1] Touring as the opening act for bands like Marilyn Manson and Queens of the Stone Age, she subsequently released her third album, Fatherfucker (2003).

Peaches' songs have been featured in films such as Mean Girls, Waiting..., Jackass Number Two, My Little Eye, Drive Angry, and Lost in Translation.

Her music has also been featured on television shows such as Orphan Black, Lost Girl, The L Word, South Park, Skam, The Handmaid's Tale, 30 Rock, True Blood, Fresh Meat, Full Frontal with Samantha Bee, The Boys, Sex Education, and Letterkenny, and has been used for the promotion of Dirt.

[7] As a teenager, Nisker appeared in two plays alongside future Barenaked Ladies singer Steven Page, including a musical, My Brother's Keeper.

She later released her first solo album, Fancypants Hoodlum, under the name Merrill Nisker in 1995, and subsequently developed the style and persona known as Peaches.

While visiting her old friend Jason Beck, who was enjoying modest European success as Chilly Gonzales in his new home base of Berlin, Peaches landed a one-night gig.

The label offered her the chance to record a new album, The Teaches of Peaches, back home in Toronto, and the already-completed Lovertits EP was released in the summer of 2000.

[17] Peaches appeared on the British TV show Top of the Pops, but her performance was deemed too racy to be aired.

She later made a big-budget video for the song "Set It Off", in which she sat in a locker room as her pubic and armpit hair grew to Rapunzel length.

[21] In 2003, Peaches released her second album Fatherfucker on XL/Kitty-Yo after years of touring and opening for artists like Marilyn Manson and Queens of the Stone Age.

[28] Peaches enlisted some of her contemporaries to co-produce a number of tracks including Simian Mobile Disco, Soulwax, Digitalism and Shapemod.

Long time friend and collaborator Chilly Gonzales co-wrote some of the songs on I Feel Cream and Shunda K (the voice of Yo Majesty) featured on the track "Billionaire".

In 2010, Peaches and backing band Sweet Machine once again toured Australia performing at the sold out Big Day Out (BDO) festivals and at a series of sideshows.

[30][31] In March 2010, the copyright owners of the musical Jesus Christ Superstar denied Peaches permission to perform her one-woman version that she was planning to stage in Berlin.

After receiving the attention of several media outlets, Peaches successfully negotiated with those rights-holders, and the musical was performed on 25–27 March at Berlin's HAU1.

[33] Travis Jeppesen stated in his review for Artforum, "Not only did Peaches set it off, she managed to surprise us all by showing off an expansive vocal range, a musician's natural sensitivity to the dynamics of Andrew Lloyd Webber's score, and an emotive prowess that is rarely if ever displayed in her own, less holy, music.

It was co-written by Gonzales and Céline Sciamma (who directed/wrote Water Lilies and Portrait of a Lady on Fire) was directed by Adam Traynor and produced by Nicolas Kazarnia.

Other musicians who have released tribute singles as part of the series include The Horrors, Primal Scream, Klaxons and Bruce Springsteen.

"[42] In May 2016, Peaches appeared in a fourth-season episode of the Canadian TV series Orphan Black as herself, performing "Bodyline" in a club.

In February 2019, Peaches made her debut with the Staatstheater Stuttgart, co-directing and performing as Anna I in Kurt Weill's/Bertolt Brecht's Die sieben Todsünden.

[44] Peaches' song "Boys Wanna Be Her" is featured in the 2022 film The 355 starring Jessica Chastain and Diane Kruger.

[48] Peaches lists John Waters, Cindy Sherman, Paul McCarthy and the films Tron, Grease, Liquid Sky and Phantom of the Paradise as inspiration for the visuals in her live shows.

Taking a bold and unexpected approach to the topics of sex, feminism, queerness, gender, and new millennium politics, Peaches calls her WJIT presentation "a deconstructed musical in 14 scenes".

Her lyrics and live shows consciously blur the distinction between male and female; for example, she appears on the cover of her album Fatherfucker with a full beard.

"[56] "This filmed version of Peaches' epic stage performance in Berlin tells the loosely biographical tale of her rise to stardom and a romance that ends in heartbreak.