The song received mostly positive reviews from critics, praising Peaches' singing and versatility when compared to her previous work.

Heather Phares of Allmusic wrote,"'Talk to Me' is a standout, with Soulwax providing an electro-soul backdrop for some of Peaches' most powerful singing.

"[3] Conversely, Darren Carle of The Skinny gave the song 2 out of 5 stars, commenting, "'Talk To Me' is a plea to a partner to open up, where once she would have rather shoved her crotch in their face.

[6] In the music video for "Talk to Me," Peaches is seen in an abandoned house wearing an outfit made out of faux human hair.

"[11] On October 26, 2009, Peaches appeared on the French television show Canal+ Album de la Semaine and performed "Talk to Me".