The Pedee people, also Pee Dee and Peedee, were a historic Native American tribe of the Southeastern United States.

[10] Traditionally, there was speculation that an early trader, Patrick Daley, carved his initials, P.D., on trees along a trail within the vicinity of the modern Pee Dee River, leading to the region and river's present name, potentially being imposed also onto the indigenous tribe, however, some scholars and writers have disagreed with this theory.

[11] The Pee Dee were part of the South Appalachian Mississippian culture[12] that developed in the region as early as 980 CE,[13] extending into present-day North Carolina and Tennessee.

[12] Town Creek Indian Mound in Montgomery County, North Carolina is a proto-historic Pee Dee culture site.

[16] Historian Charles M. Hudson believes their migration may have been an effort to avoid Spanish slave raids along South Carolina's coast.

[17] In 1567, Spanish explorers encountered the village Vehidi on the Pee Dee River, believed to be a Pedee settlement.

The Winyah and Cape Fear Indians migrated from the Atlantic Coast up the Pee Dee River to the trading post.

As a result, most of the Tuscarora left the area and migrated north, reaching present-day New York and Ontario to join the related Haudenosaunee Confederacy of Iroquois tribes.

[21] In 1715, English mapmakers recorded a Pedee village on the west band of the Pee Dee River's central course.

[22] The political relationships formed between the Pedee and other tribes in the area at this time carried over into their alliances of the Yamasee War.

[22] In 1751, at an intertribal conference in Albany, New York, the Pedee were recorded as being a small tribe living among European colonists.