Pedro Téllez-Girón, 1st Duke of Osuna, 5th count of Ureña (29 July 1537 – 13 September 1590) was a Spanish nobleman and administrator.
Born at Osuna, he was the eldest son of Juan Téllez-Girón, 4th Count of Ureña and of María de la Cueva y Toledo, daughter of Francisco Fernández de la Cueva, 2nd Duke of Alburquerque.
In 1552, aged 15, the future duke married Leonor Ana de Guzmán y Aragón (c.1540 – 23 November 1573), daughter of Juan Alfonso Pérez de Guzmán, 6th Duke of Medina Sidonia.
On 2 February 1575, he married again, this time his cousin, Isabel de la Cueva y Castilla, with whom he had another two children.
Among his children from the first marriage, he had: It is reported that being already a Duke he had an illegitimate son, known as the theatrical author Tirso de Molina.