Juan de Zúñiga y Requesens (died 1586) was Viceroy of Naples, 1579–1582.
Later, as a governor of the Duchy of Milan and of the 17 provinces of Flanders, his naval force fought back the Ottoman vanguard.
He then took part in the negotiations with Pius V to set up the Holy League to counteract naval piracy and the Turkish invasion of Suleiman I the Magnificent, (1520–1566), which led to the Battle of Lepanto in 1571, the successfully Spanish bombing of the remnant of the Ottoman fleet at Alger and Tripoli, and the plundering of the costal region of Anatolia, which result in the decisive defeat of Ottoman invasion of Western and Southern Europe.
He then married the Sicilian noblewoman Giulia Barrese, thus becoming Prince of Pietraperzia.
While in Naples he recruited ships and people (in support of the claims of King Philip II of Spain whose mother had been a Portuguese princess) to attack and conquer (with the support of a part of the Portuguese nobility) the city of Lisbon, Portugal.