[1] Serrano is also the president of Puerto Rico Para Todes, a non-profit LGBTQ+ and social justice advocacy organization he founded in 2003.
He is a former advisor to former New York City Council Speaker Melissa Mark Viverito[2] and former San Juan Mayor Carmen Yulín Cruz.
He attended primary and secondary school at the Colegio La Piedad and later studied communications at the University of Puerto Rico, Rio Piedras Campus.
[5] He began his career in activism when he served as Director of Policy and Media for the Fundación de Derechos Humanos (Human Rights Foundation) in Puerto Rico.
Later, he served as Director of Communications of LLEGO, the National Organization for Lesbian, Gay, Bisexual and Transgender Latinos in the United States, which was based in Washington, DC.
He then worked for seven years as Director of Public and Media Relations for the National LGBTQ Task Force, one of the LGBTQ+ movement's leading organization in the United States.
[14] He has also been the keynote speaker at various conferences such as the 9th LLEGO meeting – the National Organization for Lesbian, Gay, Bisexual and Transgender Latinos/as, in the Second Educational Day Against Homophobia and the Third Colloquium "Del otro la'o?
In 2010, thanks to a campaign initiated and led by Serrano, the #1 Puerto Rican television program, SuperXclusivo, publicly apologized[16] to LGBT communities and people living with HIV, for using derogatory language against them.
In late 2012 and early 2013, Serrano was one of the leaders and spokesperson[18] of the Boycott La Comay, a movement supported by more than 80,000 people which resulted in the cancellation of SuperXclusivo a program of WAPA TV.
[20] In mid-2014, with just one month to prepare, Serrano and his organization "Puerto Rico Para Todes" took charge of the LGBT Pride Parade of Boquerón.
[21] Together with his brother Héctor and his company Mújica Group, he produced the largest parade in the history of Puerto Rico with more than 40 thousand people in attendance, according to police and media.
Also, he collaborated with Representative Luis Vega Ramos in the filing of House Bill 488[26] to include sexual orientation, marital status and gender identity in the protections of Law 54 that regulate domestic violence.
Also, Serrano was instrumental in pushing the administration to issue an executive order to allow transgender people to change their sex markers on driver's licenses.
In an effort led by Lambda Legal, four couples and "Puerto Rico Para Todes" joined the lawsuit in June 2014.
[30] Marriage equality became a reality in the United States in June 2015 and in Puerto Rico it was reaffirmed by a decision from the federal appeals court in July of that same year.
[38] Serrano has received numerous awards for his work towards social justice and for the rights of the Puerto Rican and Latino LGBTQ+ communities.
The Latino Queens LGBTQ+ community, through Jessenia Marie Rosa, gave a recognition to Serrano as the leading activist at the Paparazzi Awards in New York City.
At the end of 2012, he was named one of the main protagonists of 2012 by the magazine Caras in a collector's edition that recognizes the most outstanding figures of the year in Puerto Rico.
In December, the University Gardens High School dedicated its Puerto Rican celebration to Serrano for his activism in creating a more just society.
[49] Serrano was also recognized as the Leader of the Year by the LGBTQ+ PR, International Weddings, The Experience held at the Convention Center in San Juan.