[5][6] In 1955, Ramos began his major league career with the Senators, knowing no English, which he learned by watching cowboy movies.

[8] He had only one winning season with the lowly Senators and Twins over the next six years (12–10 in 1956), and led the American League in losses from 1958-1961, chiefly as a starting pitcher.

[16] On April 2, 1962, the Twins traded Ramos to Cleveland Indians in exchange for Vic Power and Dick Stigman.

[8] Ramos played almost the entire 1964 season for Cleveland, starting 19 of 36 games in which he appeared, with 5.14 ERA and 7–10 record.

[8] On September 5, 1964, Cleveland traded Ramos to the Yankees for $75,000 and two players to be named later (after the season, the Indians received Ralph Terry and Bud Daley).

[17] The Yankees traded for Ramos to improve their relief pitching staff during a tight pennant race.

[8][22] Because the trade came after August 31, Ramos was not eligible to pitch in the World Series, which New York lost in seven games to the Bob Gibson-led St. Louis Cardinals.

[23][24] As a Senator, in his second big-league season, Ramos surrendered one of the more memorable home runs in the career of Yankees slugger Mickey Mantle.

On May 30, 1956, Mantle tore into a Ramos pitch and nearly drove it out of Yankee Stadium, hitting the facade of the top deck in right field.