It is endemic to northwestern Borneo and known from Sabah and Sarawak (Malaysia),[1][2] although its distribution is likely to be broader and might extend to Kalimantan (Indonesia).

[6] Based on just one clutch, there are about 10 eggs measuring 2.8 mm (0.11 in) in diameter;[3] low fecundity is typical for the genus.

[1][3] Natural habitats of Pelophryne misera are montane elfin forests above 1,500 m (4,900 ft) asl.

Adult toads are largely terrestrial and live in leaf-litter, rock crevices, and holes in the ground.

[1] Pelophryne misera is threatened by habitat loss caused by logging, although this mainly takes place at lower altitudes.