Pemigewasset House was a grand hotel in Plymouth, New Hampshire.
In 1841 Denison Burnam turned it into Pemigewasset House, and it tripled in size by 1859 with a grand dining room and railroad depot among the additions.
A fire destroyed it in 1862, and a new four-story hotel was constructed on the site.
It was served by the Boston, Concord, & Maine Railroad with its own depot.
Guests included President Franklin Pierce, a regular, and Nathaniel Hawthorne who died at the hotel.