1 purchased the building for $2,500 (USD),[7] and the structure was used as a public school until 1907, when it was sold to the local fire department.

The building is still used by the Penfield Fire Company, and is visible behind the modern firehouse in the Four Corners.

[12] A new union school building was constructed in 1907 at 2070 Five Mile Line Road, just a little north of the Four Corners.

The new building was faced in brick, Colonial in design, three stories high, with eight class rooms, and a combination gymnasium and auditorium seating 500.

Altogether the combined grade and high school building consisted of about 40,000 square feet of space.

[17] In September 1934, Penfield High School had five "post graduates", four seniors, eleven juniors, thirty-seven sophomores, and forty-three freshmen.

[31] The expansion added a gymnasium, expanded facilities, and a new 14 room elementary school in the rear of the building.

Before World War II, the Indian Landing school was fairly small, graduating, for example, only nine students from eighth grade in 1936,[38] increasing to 27 graduates by 1941[39] In 1941, Indian Landing School District residents voted to build a new building, at a cost of $190,000.

[40] Construction was delayed by the war (,[41] but authorization for the new school, at 16 class rooms and an anticipated cost of $470,000 was granted by the New York State Education Department in 1946.

[45] The Indian Landing district had only two alternatives: build their own small high school, which would have been expensive, or be annexed by Penfield Central, located to the east.

The Indian Landing district voted for the annexation in April 1954,[47] and the voters of Penfield approved the merger three months later.

[50][51] The addition of the Brighton territory also greatly increased the tax basis of the whole district, as the assessed valuation of the real estate in the Indian Landing School District was $10.5 million (USD), nearly twice that of the pre-annexation Penfield Central District ($5.6 million)[48] The annexation greatly sped up plans for a new Penfield High School building.

With the addition of Indian Landing students, two new Penfield elementary schools were quickly planned.

[59] The newly purchased land was intended for a new high school building, and increased the size of the School District's campus from Five Mile Line Road to Baird Road to 61 acres.

The district resubmitted the high school proposal for a second vote, without the swimming pool option, but voters again failed to approve it by the required two thirds majority May 21, 1956.

[18][66] The two-story academic wing included the following: 1) a three room home economics suite, which included four kitchens, sewing and laundry center; 2) an audio visual screening and work room; 3) a library accommodating 8,000 books; 4) a business education area with secretarial practice and typing practice rooms; 5) a double-size art room, with kiln; 6) chemistry, physics, biology and general science rooms, each with laboratories separated from the classroom space; 7) four math classrooms; 8) four citizenship education class rooms; 9) six English classrooms. The new building also included: 1) a cafeteria with seating for 500; 2) wood and metal shop classrooms, with the metal shop designed with a garage door entrance to accommodate auto shop education; 3) an auditorium seating 1,000, with a stage 68 feet wide and 28 feet deep; 3) a double-size gymnasium 110 feet by 90 feet, with a motor driven partition, allowing it to be separated it into two sections, and bleacher seating for 1,500 spectators, plus locker and shower rooms and 5) offices for administrators, guidance counselors and school nurses.

[71] The district proposed building a fourth elementary school on the Panorama Plaza area, on the west side of Panorama Trail Road about five hundred feet from Penfield Road, at a cost of $1,450,000 (USD).

[20] With rapid suburban growth and the addition of the Indian Landing school district, the size of the graduation class from Penfield High School, unchanged in the decade preceding 1955, grew tenfold in the next ten years.

[91] The first recorded protest by high school students at Penfield was a cafeteria boycott in 1959.

On January 14, only about 13 of the 600 high school students purchased lunch at the cafeteria; the rest brought food from home.

Wallace J. Howell, the high school principal, met with student leaders that afternoon, and settled the dispute.

[92] With tongue somewhat in cheek, the editorial page of the metropolitan newspaper saluted the student's "gastronomical gusto" revolt against bland food.

Penfield offers numerous electives in arts, music, engineering, and business.

The longtime Boys' and Girls' cross country, indoor, and outdoor track head coach, Dave Hennessey, holds the record for the most high school cross country wins in national history with over 900.

[109] In 1950 Penfield High School beat Scottsville 5-2 to win the Class C Monroe County Soccer Championship.