[1][2][3] The former Pennsylvania Route 2 was the designation for the Lackawanna Trail and was formed in 1924,[5] running south to north from Philadelphia to the New York state line for a distance of 163 miles (262 km).

[4] The route passed through Philadelphia, Montgomery, Bucks, Northampton, Monroe, Wayne, Lackawanna, Wyoming, and Susquehanna Counties.

[8] Rand McNally lists an extension of the Lackawanna Trail to Hackettstown, New Jersey, where it met the William Penn Highway.

The original Pennsylvania Route 3 was the designation for the William Penn Highway running from Hanover Township to Easton.

[10] The route passed through York, Cumberland, Dauphin, Perry, Juniata, Snyder, Northumberland, Lycoming, and Tioga Counties.

Pennsylvania Route 13 was a 169-mile-long (272 km) state highway that ran through Franklin, Cumberland, Dauphin, Lebanon, Berks, Montgomery, and Philadelphia Counties.

Pennsylvania Route 22 was a 60-mile-long (97 km) state highway that ran through Lehigh, Carbon, and Luzerne Counties.

When the highway was truncated in 1932 along Susquehanna Street from Allentown to Bethlehem, its previous alignment was designated as U.S. Route 22.

The northern terminus was at Pennsylvania Route 549 a half-mile south of the New York-Pennsylvania border in Wells Township.

The original Pennsylvania Route 118 was located in Beaver County and ran from Pine Street in Hookstown to PA 18 (Frankfort Road) near Shippingport.

Cooks Ferry was used to cross the Ohio River and join PA 168 northbound in Midland until 1964 when it was replaced by the Shippingport Bridge.

The original Pennsylvania Route 121 ran entirely in Greene County from the WV/PA state line near Point Marion to PA 21 in East Waynesburg.

Pennsylvania Route 126 was a 23-mile-long (37 km) state highway located in Fulton and Bedford Counties, running from US 522 in Warfordsburg to US 30 in Breezewood.

The original Pennsylvania Route 181 ran for approximately 3 miles along the Somerset County side of the Youghiogheny River from the MD/PA state line to U.S. 40 in Addison Township.

This widened the river from Confluence to the state line, sinking the designated PA 181 road in the process and calling for its decommissioning by 1946.

Pennsylvania Route 189 in Erie County (a/k/a Hare Creek Road) was the designation for what became an alignment of PA 426 (southern segment) from U.S. 6 in Corry to the PA/NY state line in Wayne Township.

Pennsylvania Route 229 was the designation for Cedar Crest Boulevard between Walbert Avenue (US 309/PA 29) in Wennersville and Chestnut Street (PA 29) in Emmaus.

Pennsylvania Route 319 in Fayette County ran from the WV/PA state line in Lake Lynn to U.S. 40 in Hopwood.

Pennsylvania Route 602 in Susquehanna County ran from U.S. 11 in Hallstead to the PA/NY state line six miles north.

As a result, 1.2 miles of its new designation ran concurrently with PA 651 from Market Street in Darlington Borough to Ashwood Road in Big Beaver.

Pennsylvania Route 709 was the designation for the road linking the Riverton–Belvidere Bridge in Riverton to US 611 east of Martins Creek.

In 1961, with the opening of a new interchange to the Penn Lincoln Parkway in Green Tree, the former PA 802 segment from the intersection of Greentree and Cochran Roads to the intersection of Greentree Road and Mansfield Avenue was reassigned as a part of the new PA 121, having been decommissioned from its original route in 1950.

Pennsylvania Route 855 in Butler County ran from the borough of Mars to PA 68 in Evans City.

A local attraction along this route was feeding tame fish in a small pond near a gas station in Callery.

Pennsylvania Route 881 began at the intersection of Walnut Street and Long Run Road in Versailles and ran northbound to U.S. 30 in East Pittsburgh.

The road connected farmland in Forward Township with Elizabeth and PA 31 and formed part of an outer beltline of Allegheny County.

Pennsylvania Route 909 (PA 909) was a 6-mile state road that ran across and parallel to the Allegheny River through Oakmont, Plum, New Kensington and Lower Burrell, northeast of Pittsburgh.

Pennsylvania Route 918 in Bedford County first ran from the MD/PA state line to PA 326 in Southampton Township.

Pennsylvania Route 968 in Jefferson County first ran from U.S. 322 in Brookville to an unnumbered road in Warsaw Township.

Pennsylvania Route 998 ran along the segment of West Canal Road from U.S. 30 northbound to PA 234 in Paradise Township/York County.