From the state line, the route heads north-northwest as two-lane undivided Anthony Highway through farmland with some trees and homes.

Here, the route turns northwest to form a concurrency with PA 16 on East Main Street, passing homes and businesses before continuing into the downtown area.

The route leaves Waynesboro for Washington Township again and becomes Anthony Highway, passing more development before heading into a mix of farms and woods.

The road curves north and passes a golf course and residential development in the community of Ledy before heading through Pond Bank.

Farther northwest, the route runs through farmland with some residential and commercial development, and gains a center left-turn lane as it passes to the northeast of the Chambersburg Mall.

Past this interchange, the route narrows to a two-lane undivided road and turns north and northwest through fields and woods to bypass the community of Scotland, coming to a bridge over Norfolk Southern's Lurgan Branch.

The road curves west and then northwest and becomes Cumberland Highway, running through farmland with some woods and residential and commercial development.

The road crosses into Letterkenny Township and continues north and then northwest through a mix of fields and woods with some development along the eastern border of the military installation.

The route curves northeast and heads into the community of Pleasant Hall, where it passes homes and crosses PA 533.

The route runs through more rural land and curves northwest, passing over the Conodoguinet Creek again and heading back into Letterkenny Township.

PA 997 curves north and passes some residential development before heading into wooded areas and crossing the creek a third time and reentering Lurgan Township.

Farther northeast, the route passes businesses and comes to a ramp providing access to the Pennsylvania Turnpike (I-76) at the Blue Mountain interchange.

PA 333 was designated in 1928 to run from US 30 in Chambersburg northeast to US 11 in Shippensburg, heading north on North Franklin Street and Letterkenny Road to Pleasant Hall before heading west to Upper Strasburg, northeast to Roxbury, east to Newburg, and south to Shippensburg.

[8] In 1937, PA 997 was extended south from Waynesboro to MD 60 at the Maryland border, following Potomac Street and Wayne Highway, and was extended northwest from Fayetteville to US 11 in Green Village, following Mont Alto Road, Main Street and Mount Pleasant Road before picking up its current alignment.

The truck route begins at PA 997 in Green Village by heading southwest concurrent with US 11 on Philadelphia Avenue, a three-lane road with a center left-turn lane that passes through a mix of farmland and residential and commercial development.

The road passes through agricultural areas with some industrial development, crossing CSX's Lurgan Subdivision railroad line.