The road heads into open farmland, making a turn to the northeast and crossing PA 416 in the community of Welsh Run.

The route crosses the West Branch Conococheague Creek and continues through more agricultural areas, coming to a junction with PA 16.

The route turns north onto Warm Springs Road and passes more agricultural surroundings before heading into wooded areas.

[2][3] The road enters St. Thomas Township and passes through the residential community of Williamson before turning northeast into farmland with some woods and homes.

Farther north, PA 995 enters increasing areas of rural residential development in the community of Sunbeam.