It turns northwest through a mix of hilly farms and woods with some homes, reaching the Virginville and becoming Main Street.

The road enters more wooded surroundings and makes a few sharp turns prior to heading west into the borough of Lenhartsville.

[3][4] Upon leaving Lenhartsville for Greenwich Township again, PA 143 becomes unnamed and reaches a partial cloverleaf interchange with I-78/US 22.

Following this intersection, the road passes through more rural areas as it runs to the west of Ontelaunee Creek and the Wanamaker, Kempton and Southern Railroad.

At this point, the road turns more to the east and passes the terminus of the Wanamaker, Kempton and Southern Railroad as it heads into more agricultural areas with some homes.

From this intersection, the route continues farther east, curving southeast and crossing Ontelaunee Creek.