The route crosses Crooked Creek and continues into a mix of farmland and woodland with occasional homes, curving to the north.

The road crosses into Plumcreek Township and passes through more rural areas, turning to the north-northeast as it heads west of the Keystone Generating Station.

PA 210 comes to an intersection with US 422 southeast of the borough of Elderton and continues through more agricultural areas with some woods and residences, running a short distance to the northwest of Plum Creek.

Farther northeast, the road crosses the North Branch Plum Creek and heads into more forested areas with a few fields and development, running near the southeastern shore of Keystone Lake.

Past the lake, the road turns northeast through more farmland and woodland with some homes, passing through the residential community of Sagamore on Main Street before running through more rural areas.