The road heads through open agricultural areas, passing through Graziers Mill.

The route continues through more agricultural areas before coming to the community of Spring Mount, where it turns west to ascend forested Bald Eagle Mountain.

At this point, the route turns north onto an unnamed four-lane divided highway, passing through woods and coming to an intersection with US 220 Business in the community of Bald Eagle.

[2][4] PA 350 heads into Taylor Township in Centre County and becomes Old Tyrone Pike, turning northwest and running through more forests.

PA 350 heads into a mix of fields and woods with some residences, becoming the border between Rush Township to the west and the borough of Philipsburg to the east.