PA 382 is a two-lane undivided road that runs through rural areas in the northern part of York County.

Farther west, the road has an interchange with Interstate 83 (I-83) in Newberrytown and an intersection with PA 177 in Lewisberry.

The road curves northwest and becomes the border between the borough of Lewisberry to the northeast and Newberry Township to the southwest, intersecting PA 177.

The road heads through a mix of farms, woods, and homes, passing through the community of Nauvoo.

This change was made as part of the construction of I-83 in order to provide a numbered route at each interchange.