The road heads through areas of farms and woods, passing west of a park and ride lot and reaching a diamond interchange with I-81, where it becomes a four-lane divided highway.

From this point, the route heads southeast and crosses the Conodoguinet Creek, continuing south into business areas and intersecting US 11 in Hogestown.

Past this intersection, PA 114 becomes two-lane undivided Hogestown Road and runs through agricultural areas with some housing developments, curving southeast.

The road continues east through a mix of farmland and woodland with some homes, crossing into Lower Allen Township and running through the residential community of Lisburn on Main Street.

[2][3] PA 114 crosses the Yellow Breeches Creek into Fairview Township in York County and becomes Cedars Road, heading through rural areas with a few residences.

PA 114 runs through more residential areas prior to ending at SR 1003 (Old York Road) west of the Capital City Airport near New Market.

By this time, the current route east of Mechanicsburg was an unpaved road, with a small paved section to the west of the Yellow Breeches Creek.

The present-day route east of there was designated as the northernmost part of PA 24, which reached its northern terminus at US 111 (Old York Road) in New Market.

[11] In the 1970s, the route was extended north from US 11 in Hogestown to PA 944 in Wertzville, with an interchange at I-81; the portion of the road between I-81 and US 11 was widened into a divided highway.