PA 392 is a two-lane undivided road that runs through rural areas in northern York County.

The route heads east and curves south before turning north to come to an interchange with Interstate 83 (I-83).

PA 392 curves back east and passes through Yocumtown before reaching its terminus.

The route curves to the southeast and runs a short distance to the west of I-83.

[7][8] With the creation of the U.S. Highway System in 1926, US 111 became concurrent with PA 4 on the Susquehanna Trail, which was paved.