The southern terminus is at Route 46 in the Keating Township neighborhood of Farmers Valley.

The highway passes Moody Hollow, where it turns northward and crosses the railroad tracks.

PA 446 enters Larabee, where it passes over the Allegheny River and the Buffalo Line railroad line, which is owned by Norfolk Southern and operated by the Western New York and Pennsylvania Railroad, before it intersects with the northern terminus of PA 155.

[2] PA 446 leaves Larabee soon afterward, becoming surrounding on both sides by mountains, with the river and railroad tracks to the west.

[2] PA 446 from Farmers Valley to Larabee used to be part of Pennsylvania Route 7, which was designated in 1925.