The route, known locally as Oil Valley Road, begins at an intersection with PA 346 in the community of Duke Center (located in Otto Township).

The highway, known locally as Oil Valley Road, progresses to the northeast, intersecting with a short connector back to PA 346 (SR 9112).

PA 546 parallels the Knapp Creek, and after an intersecting with Galespie Hollow Road, the highway leaves Duke Center.

A short distance later, the highway passes through several taller mountains, some reaching as high as 2,200 feet (670 m) in elevation.

At the time, the sections of PA 546 from the community of Duke Center to a location 2 miles (3.2 km) north were incomplete.