North of Doylestown, PA 611 heads through rural areas and runs along the west bank of the Delaware River to Easton in the Lehigh Valley.

Past the sports complex, the road runs through urban neighborhoods and comes to an interchange with I-76 (Schuylkill Expressway), which heads west across Philadelphia and east toward the Walt Whitman Bridge over the Delaware River into New Jersey.

[3][4] Past Penn Square, PA 611 continues north along six-lane divided Broad Street through more commercial development and high-rise buildings in Center City.

Following this, PA 611 passes more commercial development and crosses Spring Garden Street before running to the east of Benjamin Franklin High School.

PA 611 continues past more urban homes and runs to the west of Jefferson Einstein Philadelphia Hospital between Somerville Avenue and Tabor Road.

At Grange Avenue, the Broad Street Line splits to the east to head toward its northern terminus at the Fern Rock Transportation Center.

The route turns back to the north and passes more residential development, heading to the east of Salus University before coming to an intersection with PA 73.

Farther north, the route crosses Old Welsh Road before it comes to an intersection with PA 63, at which point it enters Upper Moreland Township.

The route then becomes a four-lane divided highway and curves northwest, crossing Pennypack Creek and coming to a junction with the eastern terminus of PA 463 in Horsham.

PA 611 bends to the north-northwest and the median becomes a center turn lane, with the route passing more development and becoming the eastern border of the Biddle Air National Guard Base.

Past this intersection, the route heads to the west of The Shops at Valley Square and becomes a five-lane road with a center left-turn lane that runs north through suburban residential and commercial development.

The route bends northeast as it runs near residential and commercial development, coming to a diamond interchange with Broad Street that provides access to the Bucks County Courthouse.

PA 611 narrows to a three-lane road with a center left-turn lane and runs through a mix of farm fields and woodland with some residential and commercial development, crossing the North Branch Neshaminy Creek.

North of here, the route narrows to two lanes and passes some industrial development before heading into a mix of farms and woods with some homes and businesses and entering Bedminster Township.

The road crosses Cabin Run and bends to the north-northeast as it continues through rural areas with some development, coming to an intersection with the northern terminus of PA 413 in Pipersville.

The road continues along the canal and the river, crossing Rodges Run, and curves north to come to an intersection with the eastern terminus of PA 212 in Durham Furnace.

The route passes through Raubsville and continues north-northwest through wooded areas with sparse development alongside the canal and river, curving northeast.

PA 611 enters Upper Mount Bethel Township and heads through a mix of farm fields and woods with some homes, passing through Centerville.

The road continues north through rural land and comes to an intersection with the northern terminus of PA 512 before it heads northeast through Mount Bethel.

The road gains a second northbound lane and leaves Portland for Upper Mount Bethel Township, heading into forested areas and passing to the west of Slateford.

Past this intersection, the road passes north of the Martz Bus Terminal and a commuter parking lot serving Delaware Water Gap.

Past this interchange, the road becomes South 7th Street and crosses McMichael Creek before it heads into the commercial downtown of Stroudsburg, where it comes to an intersection with US 209 Bus.

Farther west, the road passes north of St. Luke's Hospital–Monroe Campus and widens to five lanes, coming to an at-grade intersection with the northern terminus of the PA 33 freeway, which provides access to I-80 immediately to the south.

The route becomes a three-lane road with a center left-turn lane and passes to the west of a Sanofi Pasteur plant before it comes to a junction with PA 314 in Swiftwater, where it turns into a four-lane divided highway.

PA 611 crosses into Paradise Township and reaches Wiscasset, where it intersects Woodland Road, which leads northeast to the Mount Airy Casino Resort.

The route continues through forested areas with some homes and businesses, reaching a bridge over the Delaware-Lackawanna Railroad line and becoming a four-lane undivided road.

The proposal called for extending the freeway section of PA 63 (Woodhaven Road) from Northeast Philadelphia northwest to an interchange with the Pennsylvania Turnpike (I-276) in Southampton.

[39] In September 2021, the remnants of Hurricane Ida damaged an arch culvert along PA 611 in Williams Township, resulting in the closure of this portion of road.

[45] On December 6, 2022, heavy rains caused a rockslide along PA 611 between Portland and Delaware Water Gap, resulting in the closure of this stretch of road indefinitely.

[47] The Pennsylvania Department of Transportation (PennDOT) plans to repair the road by removing loose rock from the side of Mount Minsi, after which a single lane would be reopened and long-term stabilization of the slope will begin.