begins at an intersection with US 11/US 64 (State Route 2 [SR 2], South Lee Highway) in Cleveland near Bradley Central High School.

At this intersection, the Cleveland/Bradley County Greenway also begins, following alongside Mouse Creek.

The route then enters a primarily commercial district, passing the corporate headquarters of Life Care Centers of America, and turns northeast, crossing Mouse Creek and the greenway.

About one-half mile (0.80 km) later, the bypass comes to an end at an intersection with US 11 (Ocoee Street).

[5] The state then assumed control of the remainder of the route, which was widened to four lanes in the earlier 1960s.

In 1983, when the Tennessee Department of Transportation (TDOT) modified their highway numbering system, SR 2 was rerouted onto Keith Street.

The section of US 11 between the southern terminus of Keith Street and the intersection with US 64 became part of SR 40 (which continues on US 64 into North Carolina, and the section between US 64 and Keith Street's northern terminus became part of SR 74.

It runs along SR 39 in Riceville until it reaches downtown Athens where it becomes a one-way pair just before the intersection with Woodman Street.

On the verge of departing downtown, the road has one major intersection with SR 30 (Decatur Pike westbound and Green Street eastbound), then runs along the hills of the suburbanized landscape of the outskirts of the city.

[9] It starts at an intersection with US 11 and State Route 251 (SR 251) outside of Lexington and heads toward the center of town.

between Jefferson and White streets was changed to be one-way northbound, and southbound US 11 Bus.

It is not a common Virginia Department of Transportation (VDOT) road because it only runs from the SR 262/US 11 intersection to US 11/US 250 in the downtown area.

was an alternate route of US 11 between Camp Hill and Wormleysburg in Pennsylvania, passing through Lemoyne.

became concurrent with US 111, and the two routes continued northeast along Market Street, crossing a Pennsylvania Railroad line as the road curved northwest to follow the west bank of the Susquehanna River.

[11] With the creation of the U.S. Numbered Highway System in 1926, Market Street through Camp Hill and Lemoyne was designated as part of US 11/Pennsylvania Route 13 (PA 13), which crossed the Susquehanna River into Harrisburg on the Market Street Bridge.

[22][17] In 1941, the eastern terminus of the bypass route was cut back to Wormleysburg after US 11/US 15 were realigned to replace PA 14 on Front Street.

was replaced with mainline US 11, with the former alignment of US 11 between Camp Hill and Wormleysburg designated as US 11 Alt.