The northern terminus is located several miles north of Altoona, east of Pinecroft, at an interchange with Interstate 99 (I-99) and US 220, at exit 39.

Approaching the downtown area, PA 764 splits into the 6th and 7th Avenue one-way pair and enters the commercial district of Altoona.

[3] The PA 764 one-way couple remains parallel and separate for 2.4 miles (3.9 km), into the northern portions of Altoona.

In the northern section of the city, the two pairs merge and turn right onto Lloyd Street, while Sixth Avenue Road continues to the north.

Outside of Altoona, PA 764 merges onto US 220 Business, to begin a long overlap with the route on Pleasant Valley Boulevard.