PA 850 comes to an intersection with PA 75 in the community of Honey Grove, where it briefly turns south to form a concurrency with that route and cross Laurel Run, before heading southeast into forested areas and crossing through a gap in Tuscarora Mountain, turning to the northeast.

[2][3] PA 850 crosses into Northeast Madison Township in Perry County and runs east through more forests with a few agricultural clearings and residences, passing through Walsingham.

The route turns south into open agricultural areas, heading more to the southeast as it comes to a junction with PA 17 in Kistler.

The route heads south past homes prior to turning east out of Loysville and running through farmland with some woods and residences.

The road heads into forested areas and turns northeast in Falling Spring, running a short distance to the north of the Shermans Creek.

The route heads east and enters Carroll Township, coming to an intersection with PA 34 in Dromgold.

PA 850 continues through more rural valley areas, passing through Grier Point, crossing the Appalachian Trail, and running through Keystone.

PA 850 enters the borough of Marysville and becomes Valley Street, passing homes and coming to its eastern terminus at US 11/US 15.

The same year, the section of the current route between Landisburg and Dromgold was designated as the northernmost portion of PA 233, which was unpaved.