The stretch of US 11 between I-76 and I-81 is known as the "Miracle Mile" since it contains plenty of traveler services including restaurants, gas stations, lodging, truck stops, and shops.

Rumored to have originally been a Native American trail, it is now a significant center of urban sprawl serving much of Harrisburg's western suburbs.

US 11, in contrast, continues to parallel the main Susquehanna River, passing through municipalities such as Danville, Bloomsburg, and Berwick (where it crosses I-80) prior to reaching the Wilkes-Barre area.

US 6 joins US 11 westward to Factoryville, where US 11 separates from US 6 and resumes its northerly trek through Susquehanna County to the New York–Pennsylvania border in Great Bend Township.

[2] It parallels the current rail route between Scranton and Binghamton, New York, the Nicholson Cutoff, allowing views of the massive earthworks and the Tunkhannock Viaduct.

Prior to 1941, US 11 followed Walnut Bottom Road between Shippensburg and Carlisle while PA 33 ran along the Governor Rittner Highway.

At the end of Green Ridge Street at North Scranton Junior High School, they turned right onto Main Avenue entering the Providence section of the city.

US 11 continued on West Market Street to Saltry Place, where it turned left for one block then right onto the North Scranton Expressway.

Route 11 in Pennsylvania is where Nan Adams has her tire blow-out in the "Twilight Zone" episode "The Hitch Hiker".