The road heads through agricultural areas with some homes in the Brush Valley before turning northeast and crossing forested Nittany Mountain.

Farther east, PA 880 crosses into the borough of Loganton and becomes West Main Street, passing homes.

After this, PA 880 passes a few fields as it turns northwest, crossing into the Tiadaghton State Forest and heading into Crawford Township.

Farther north, the road leaves the state forest and passes through residential Rauchtown, heading through more wooded areas.

[2][4] PA 880 crosses into Limestone Township in Lycoming County and becomes an unnamed road, heading north-northwest into agricultural areas before turning northeast.