Her humor and unconventional approach to the documentary form, including the use of archival Super 8 footage and YouTube videos, have earned her critical acclaim.

She received an AB in American Culture and Media Studies at Vassar College in 2001 and an MFA in Integrated Electronic Arts at Rensselaer Polytechnic Institute in 2005.

[10] a mostly-animated experimental documentary about con-man and quack, John Brinkley, world premiered at Sundance Film Festival, where it won the Special Jury Award for Editing.

[2] In 2016, Lane discovered that the Tribeca Film Festival was planning to screen Vaxxed, an anti-vaccination documentary directed by Andrew Wakefield.

[32] The Wall Street Journal wrote that the "highly personal view of the Nixon years is, for obvious reasons, a sad and wrenching one - a film that is nonetheless filled with spirit, humor, and a bountiful sense of irony.”[33] Amy Entelis, senior vice president for development for CNN Worldwide, praised the film for its “original material” and “unconventional” storytelling.

[34] After encountering Charlatan, an authorized biography written by Pope Brock, in her local public library in 2009, Lane developed an interest in John Romulus Brinkley, a doctor who attempted to cure impotence via goat testicle transplantation in 1917.

[43][44] Lane has described the film as both "YouTube body horror,"[45] and a "work of media archeology" which asks the questions, "When doctors send you away, to whom do you turn for help?

"[46] Lane was inspired to make the film by reading a 2013 essay in Harpers Magazine by Leslie Jamison describing the phenomenon.

[52] The Abortion Diaries is a short documentary film released in 2005 which Lane completed as her MFA thesis project at iEAR Studios, Rensselaer Polytechnic Institute's electronic arts graduate program.

Critics have written of the film, "[t]hough the concept is simple, it is also profoundly radical"[53] and described it as "clear-eyed and surprisingly compelling".

Lane looked "literally all over the Internet" for advice to help her handle her emotions, but found mainly pro-life literature disguised as unbiased pregnancy resources and pro-choice websites that failed to offer much beyond statistics.

It became important organizing and discussion tool, screening at hundreds of colleges, churches, community centers, basements, and bars in every US state.

The Voyagers is an experimental documentary that tells the story of the NASA project to launch two spacecraft, each carrying golden phonograph records holding a wealth of human culture, into space in 1977.

In the process of putting together these time capsules of human experience, Carl Sagan and the project's creative director, Ann Druyan, fell in love.

Their story resonated with Lane, who created a personal take on it for her own wedding, as a meditation on the nature of love in an uncertain universe.

[63][64] Lane said the film is "a valentine to Carl Sagan and the way that he ... embodies the place where scientific skepticism meets child-like awe and wonder and joy and optimism.

"[67] Critic Andrew S. Allen described the film as "a profound story about love and the fearless ability of the human spirit to stand in awe of its vastness, to dream of its mysteries, and to catch a glimpse of its incomprehensible complexity, and, knowing what triumphs and heartache lie ahead, still boldly jump in headfirst.