[3][1] Nuts!, narrated by Gene Tognacci,[4] documents the life and career of John R. Brinkley (1885-1942),[4] a Milford, Kansas druggist-turned physician who purportedly discovered a cure for male impotence by implanting goat testicles into the scrotums of his human patients.

[6] Brinkley is credited for building the world's most powerful radio station for the time, KFKB (Kansas Folk Know Better),[8] popularizing country or "hillbilly" music,[2] and inventing the infomercial[9][10] with his own diatribes about public health.

It is revealed late in the movie that Brinkley also faced numerous wrongful death suits, had dubious academic credentials, and had an arrest record.

[1][4][6][10][9] Voice over work is done by Andy Boswell, John Causby, Kelly Mizell, Jeff Pillars, Thom Stylinski, and Fran Taylor.

[1] On the website which accompanies the film, Lane provides readers and viewers with an extensive database called "Notes on Nuts!” with over 300 footnotes so people can check her facts and disclosing creative choices: where she stayed true to the factual record, altered the chronology of events, or "simply made things up out of whole cloth".

[10][7][2] Dennis Harvey wrote in Variety, "Lane and company created a sort of prankish ode to the classic American Dream of hard work and high ideals leading inevitably to fame, fortune and happiness.

"[10] Ann Hornaday wrote that Lane's novel use of footnotes was a welcome and unique contribution to ongoing debates about truth and ethics in documentary film, but she also expressed concern that the footnotes appeared months after the movie's release, allowing "plenty of time for viewers to internalize the filmmaker's imaginary characters and outright fictions as historical truth".