Early cartographers gave various spellings for the name, including Pennishpaska, La Riviere de Pennicpacka, and Pennishpacha Kyl.
The creek begins in two branches, one in Horsham, the other in Warminster, joining in Bryn Athyn.
[3] When William Penn founded the province of Pennsylvania in 1682, the Pennypack valley was occupied by Swedish colonists, who continued to live as English settlement began.
[3] The mills contributed to the growth of Holmesburg, the neighborhood near the mouth of the creek, and provided local farmers a place to sell their grain that was nearer than the city of Philadelphia.
As a result, many of the mills on the Pennypack closed, and by 1905 the land around it was acquired by the city for parkland.