In 1893 Spence made two drawings of Robert Louis Stevenson in Sydney; one is now in the National Portrait Gallery, London.
[2] Spence went to England after marrying Jessie Wright 30 January 1894; illustrations by him appeared in Punch, Black and White, the Graphic, and other well-known publications of the time.
In 1901 he was responsible for the illustrations to Britain's Austral Empire, mostly portraits of the leading Australian politicians of that period.
In 1905 Spence was back in Sydney and held a one-man show of his work, and in 1910 he provided 75 illustrations for the volume Australia, in Black's colour series.
The "H. M. Australian Fleet arriving at Sydney Heads" and a portrait of Rear-Admiral George Patey are at Buckingham Palace.