[5][6][7] The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes.

Through its rod domain, this protein forms complexes with envoplakin.

This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments.

[7] PPL (gene) has been shown to interact with Keratin 8[8] and Envoplakin.

[9][10] This article on a gene on human chromosome 16 is a stub.