Periplanone B is a pheromone produced by the female American cockroach,[1] Periplaneta americana.

It is a sexual attractant to male cockroaches, especially at short ranges.

[2] The activity of this pheromone was first described in 1952, but it was not until 25 years later that Persoons et al. reported the gross structure of periplanones A and B.

The stereochemical configuration and first total synthesis were reported by W. Clark Still's group at Columbia University in 1979.

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