Perlapine, sold under the brand names Hypnodine and Pipnodine, is a hypnotic and sedative of the tricyclic group which is marketed in Japan.

[1] It acts primarily as a potent antihistamine,[2] and also has anticholinergic,[2] antiserotonergic,[3] antiadrenergic, and some antidopaminergic activity.

[3][4][5][6] The drug has relatively weak affinity for the dopamine D2 receptor (IC50Tooltip Half-maximal inhibitory concentration = 1,803 nM) and, in accordance, is said to be ineffective as an antipsychotic.

[6][7] However, it retains higher affinity for the dopamine D1 receptor (IC50 = 198 nM).

[6] Perlapine is closely related to clotiapine, clozapine, fluperlapine, loxapine, and tilozepine.