Perley Brown Johnson (September 8, 1798 – February 9, 1870) was an American physician and politician who served as a U.S. Representative from Ohio for one term from 1843 to 1845.

Born in the blockhouse in Marietta, Northwest Territory (in what would be Ohio starting in 1803) Johnson attended the public schools.

Discontinued the practice of his profession in 1847 on account of ill health and lived in retirement until his death in McConnelsville, Ohio, February 9, 1870.

Perley B. Johnson, Jr. died July 18, 1863, during the charge upon Fort Wagner during the American Civil War.

[2] This article incorporates public domain material from the Biographical Directory of the United States Congress