It is one of two public high schools serving grades nine through twelve in the Perry Township, along with Southport High School.

Enrollment surpassed 2,350 students during the 2019-2020 school year, with Asian, African-American, Hispanic and multi-racial students making up a slight majority of the high school population.

[2] More than 20,000 Burmese (Chin) refugees and extended family members have moved to the Southside since 2000,[3] boosting Perry Meridian's Asian-American population above 25 percent overall by 2019.

Perry Meridian opened its doors in the fall of 1973 under principal James Head.

Perry Meridian only enrolled grades 9-11 during its first year.