In The Matrix Revolutions, Persephone warns the Merovingian that Trinity would indeed kill everyone in Club Hel to free Neo from the Train Station, simply because she is in love.

In The Matrix Resurrections, Persephone makes a quick cameo appearance through archive footage from Reloaded while Neo remembers his past adventures sixty years after bringing peace to humans and Machines.

In the video game Enter The Matrix, Persephone encounters and takes a kiss from either Niobe or Ghost (depending on whose story the player follows).

In the MMO The Matrix Online, Persephone gave the location of the Assassin's hide-out to Zion operatives in a critical mission relating to the Death Of A Destroyer event.

Before shooting her husband's employee in The Matrix Reloaded, Persephone wonders aloud, "How many people keep silver bullets in their gun?