Pesaro railway station is situated at Piazzale Giovanni Falcone e Paolo Borsellino, southwest of the city centre.

The station was opened on 17 November 1861, upon the inauguration of the final section of the Bologna–Ancona railway, between Rimini and Ancona.

In 1935, the original passenger building was replaced by the present structure, designed by the architect Roberto Narducci.

The passenger tracks are served by three platforms accessible to users through a pedestrian underpass - lifts are available.

The Intercity and High speed trains mostly link Pesaro with Roma Termini, Lecce, Ancona and Milan Central.