He was the second son of Jerome De Salis by his wife Mary, daughter of the first Viscount Fane.
He was educated with his brothers, Charles and Henry, in the Grisons, in Chur where his tutor was Johann Heinrich Lambert, and then at Eton.
[citation needed] Salis was Governor and Capitaine General of the Valtelline 1771–1773, and 1781–1783, where, it was said at the time, "with great munificence, insight and skill he hastened to relieve the poverty of the population of Chiavenna".
[citation needed] Salis was sent by his father to the Grisons where he married a second cousin in 1763, she died, morte avec une fille en couches a year later.
[citation needed] In March 1785 he inherited his mother's half share of the Bourchier-Fane estates in counties Limerick and Armagh, (Ireland).