Wisgerhof made his debut in professional football, being part of the Vitesse squad in the 1999–2000 season.

He then signed permanently with NEC, then played nine seasons for the club until making a switch in 2009 to Twente, who had sold defender Rob Wielaert to Ajax.

Wisgerhof played a notable role in this victory as he was claimed to have made an obvious schwalbe (dive), which was much commented on in the local and international press.

[2] On 30 July 2011, Wisgerhof won his second Johan Cruyff Shield with Twente after his side again defeated Ajax, 2–1.

On 10 October 2010, Netherlands senior team head coach Bert van Marwijk called him up (at age 30) to the squad for the 17 November match against Turkey.