He had married Isabella, daughter of Sir Robert Bolles, Bart, of Scampton, Lincolnshire.
Wyche was admitted a gentleman commoner at Exeter College, Oxford, on 29 April 1643, matriculating, 'aged 15,' on 6 May following.
In May 1656 he was in Italy, where Hyde procured him a passport and a testimonial in Latin, signed by the exiled Charles II.
He is believed to have died about 1699, married on 19 February 1666 Isabella, daughter of Sir Robert Bolles (Blomefield, Hist.
180), bart., of Scampton, Lincolnshire, by Mary, daughter of Sir Edward Hussey, and had issue, first, John, English envoy extraordinary at Hamburg (Boyer, Annals of Queen Anne, 1710, viii.